Cloned (Comment) | Organism |
---|---|
independent expression of isozymes FMO1 and FMO3 in Spodoptera frugiperda Sf9 insect cell microsomes via baculovirus transfection system | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobenzoic acid hydrazide + NADPH + O2 | Homo sapiens | - |
? | - |
? | |
dapsone + NADPH + O2 | Homo sapiens | bioactivation by isozyme FMO3, not FMO1, results in covalent adduct formation | ? | - |
? | |
methimazole + NADPH + O2 | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | arylamine compounds, such as sulfamethoxazole and dapsone, are metabolized in epidermal keratinocytes to arylhydroxylamine metabolites that autooxidize to arylnitroso derivatives, which in turn bind to cellular proteins and can act as antigens/immunogens, methimazole and 4-aminobenzoic acid hydrazide attenuate the protein haptenation, overview | ? | - |
? | |
sulfamethoxazole + NADPH + O2 | Homo sapiens | bioactivation by isozyme FMO3, not FMO1, results in covalent adduct formation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q01740 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
NHEK cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobenzoic acid hydrazide + NADPH + O2 | - |
Homo sapiens | ? | - |
? | |
dapsone + NADPH + O2 | bioactivation by isozyme FMO3, not FMO1, results in covalent adduct formation | Homo sapiens | ? | - |
? | |
dapsone + NADPH + O2 | isozyme FMO3, not FMO1 | Homo sapiens | ? | - |
? | |
methimazole + NADPH + O2 | - |
Homo sapiens | ? | - |
? | |
additional information | arylamine compounds, such as sulfamethoxazole and dapsone, are metabolized in epidermal keratinocytes to arylhydroxylamine metabolites that autooxidize to arylnitroso derivatives, which in turn bind to cellular proteins and can act as antigens/immunogens, methimazole and 4-aminobenzoic acid hydrazide attenuate the protein haptenation, overview | Homo sapiens | ? | - |
? | |
sulfamethoxazole + NADPH + O2 | bioactivation by isozyme FMO3, not FMO1, results in covalent adduct formation | Homo sapiens | ? | - |
? | |
sulfamethoxazole + NADPH + O2 | isozyme FMO3, not FMO1 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FMO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |