Cloned (Comment) | Organism |
---|---|
expression of isozymes FMO1-FMO5, optimized for heterologous expression, in Escherichia coli, isozymes FMO1-FMO4 are active with peptide-bound methionine, while FMO5 is inactive | Homo sapiens |
functional expression of isozymes FMO1-FMO3, in Escherichia coli | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
6.5 | - |
L-methionine | recombinant FMO3, pH 7.4, 37°C | Homo sapiens | |
6.5 | - |
L-methionine | recombinant FMO3, pH 7.4, 37°C | Oryctolagus cuniculus | |
10 | - |
L-methionine | above, recombinant FMO4, pH 7.4, 37°C | Homo sapiens | |
30 | - |
L-methionine | recombinant FMO2, pH 7.4, 37°C | Oryctolagus cuniculus | |
48 | - |
L-methionine | recombinant FMO1, pH 7.4, 37°C | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Oryctolagus cuniculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine + NADPH + O2 | Homo sapiens | - |
L-methionine S-oxide + NADP+ + H2O | - |
? | |
L-methionine + NADPH + O2 | Rattus norvegicus | - |
L-methionine S-oxide + NADP+ + H2O | - |
? | |
L-methionine + NADPH + O2 | Oryctolagus cuniculus | - |
L-methionine S-oxide + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme FMO1-FMO5 | - |
Oryctolagus cuniculus | - |
isozyme FMO1-FMO5 | - |
Rattus norvegicus | - |
isozyme FMO1-FMO5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
kidney | - |
Oryctolagus cuniculus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Oryctolagus cuniculus | - |
liver | male and female | Homo sapiens | - |
lung | - |
Oryctolagus cuniculus | - |
additional information | differential expression of isozymes in tissues | Homo sapiens | - |
additional information | differential expression of isozymes in tissues | Rattus norvegicus | - |
additional information | differential expression of isozymes in tissues | Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Met-Phe + NADPH + O2 | isozymes FMO1-FMO4 | Homo sapiens | (L-Met-S-oxide)-Phe + NADP+ + H2O | - |
? | |
L-Met-Phe + NADPH + O2 | liver microsomes | Oryctolagus cuniculus | (L-Met-S-oxide)-Phe + NADP+ + H2O | - |
? | |
L-Met-Val + NADPH + O2 | isozymes FMO1-FMO4, low activity by isozyme FMO1 | Homo sapiens | (L-Met-S-oxide)-Val + NADP+ + H2O | - |
? | |
L-Met-Val + NADPH + O2 | liver microsomes | Oryctolagus cuniculus | (L-Met-S-oxide)-Val + NADP+ + H2O | - |
? | |
L-methionine + NADPH + O2 | - |
Homo sapiens | L-methionine S-oxide + NADP+ + H2O | - |
? | |
L-methionine + NADPH + O2 | - |
Rattus norvegicus | L-methionine S-oxide + NADP+ + H2O | - |
? | |
L-methionine + NADPH + O2 | - |
Oryctolagus cuniculus | L-methionine S-oxide + NADP+ + H2O | - |
? | |
L-methionine + NADPH + O2 | free and N-terminally peptide-bound L-methionine, no activity with modified peptide-bound methionine and with N-acetyl-L-methionine, isozymes FMO1-FMO4 | Homo sapiens | L-methionine S-oxide + NADP+ + H2O | stereospecificity for formation of the D-isomer, especially by isozyme FMO3 | ? | |
L-methionine + NADPH + O2 | free and N-terminally peptide-bound L-methionine, no activity with modified peptide-bound methionine and with N-acetyl-L-methionine, isozymes FMO1-FMO4 | Rattus norvegicus | L-methionine S-oxide + NADP+ + H2O | stereospecificity for formation of the D-isomer, especially by isozyme FMO3 | ? | |
L-methionine + NADPH + O2 | free and N-terminally peptide-bound L-methionine, no activity with modified peptide-bound methionine and with N-acetyl-L-methionine, isozymes FMO1-FMO4 | Oryctolagus cuniculus | L-methionine S-oxide + NADP+ + H2O | stereospecificity for formation of the D-isomer, especially by isozyme FMO3 | ? | |
L-Phe-Met + NADPH + O2 | liver microsomes | Oryctolagus cuniculus | (L-Met-S-oxide)-Phe + NADP+ + H2O | - |
? | |
L-seleno-methionine + NADPH + O2 | liver microsomes | Oryctolagus cuniculus | L-methionine seleno-oxide + NADP+ + H2O | - |
? | |
L-seleno-methionine + NADPH + O2 | purified liver isozymes FMO1 and FMO3 | Rattus norvegicus | L-methionine seleno-oxide + NADP+ + H2O | - |
? | |
additional information | stereoselectivity of male and female liver microsomes, and of recombinant isozymes FMO1, FMO3, and FMO4, overview | Homo sapiens | ? | - |
? | |
additional information | stereoselectivity of purified isozymes FMO1 and FMO3, overview | Rattus norvegicus | ? | - |
? | |
additional information | stereoselectivity of recombinant isozymes FMO1, FMO2, and FMO3 | Oryctolagus cuniculus | ? | - |
? | |
S-benzyl-L-cysteine + NADPH + O2 | isozyme FMO1 | Rattus norvegicus | S-benzyl-L-cysteine S-oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FMO | - |
Homo sapiens |
FMO | - |
Rattus norvegicus |
FMO | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.4 | - |
- |
Homo sapiens |
8.4 | - |
- |
Rattus norvegicus |
8.4 | - |
- |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FAD | - |
Rattus norvegicus | |
FAD | - |
Oryctolagus cuniculus | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Oryctolagus cuniculus |