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Literature summary for 1.14.13.8 extracted from

  • Elfarra, A.A.; Krause, R.J.
    Potential roles of flavin-containing monooxygenases in sulfoxidation reactions of L-methionine, N-acetyl-L-methionine and peptides containing L-methionine (2005), Biochim. Biophys. Acta, 1703, 183-189.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of isozymes FMO1-FMO5, optimized for heterologous expression, in Escherichia coli, isozymes FMO1-FMO4 are active with peptide-bound methionine, while FMO5 is inactive Homo sapiens
functional expression of isozymes FMO1-FMO3, in Escherichia coli Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.5
-
L-methionine recombinant FMO3, pH 7.4, 37°C Homo sapiens
6.5
-
L-methionine recombinant FMO3, pH 7.4, 37°C Oryctolagus cuniculus
10
-
L-methionine above, recombinant FMO4, pH 7.4, 37°C Homo sapiens
30
-
L-methionine recombinant FMO2, pH 7.4, 37°C Oryctolagus cuniculus
48
-
L-methionine recombinant FMO1, pH 7.4, 37°C Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-
microsome
-
Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine + NADPH + O2 Homo sapiens
-
L-methionine S-oxide + NADP+ + H2O
-
?
L-methionine + NADPH + O2 Rattus norvegicus
-
L-methionine S-oxide + NADP+ + H2O
-
?
L-methionine + NADPH + O2 Oryctolagus cuniculus
-
L-methionine S-oxide + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme FMO1-FMO5
-
Oryctolagus cuniculus
-
isozyme FMO1-FMO5
-
Rattus norvegicus
-
isozyme FMO1-FMO5
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
kidney
-
Oryctolagus cuniculus
-
liver
-
Rattus norvegicus
-
liver
-
Oryctolagus cuniculus
-
liver male and female Homo sapiens
-
lung
-
Oryctolagus cuniculus
-
additional information differential expression of isozymes in tissues Homo sapiens
-
additional information differential expression of isozymes in tissues Rattus norvegicus
-
additional information differential expression of isozymes in tissues Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Met-Phe + NADPH + O2 isozymes FMO1-FMO4 Homo sapiens (L-Met-S-oxide)-Phe + NADP+ + H2O
-
?
L-Met-Phe + NADPH + O2 liver microsomes Oryctolagus cuniculus (L-Met-S-oxide)-Phe + NADP+ + H2O
-
?
L-Met-Val + NADPH + O2 isozymes FMO1-FMO4, low activity by isozyme FMO1 Homo sapiens (L-Met-S-oxide)-Val + NADP+ + H2O
-
?
L-Met-Val + NADPH + O2 liver microsomes Oryctolagus cuniculus (L-Met-S-oxide)-Val + NADP+ + H2O
-
?
L-methionine + NADPH + O2
-
Homo sapiens L-methionine S-oxide + NADP+ + H2O
-
?
L-methionine + NADPH + O2
-
Rattus norvegicus L-methionine S-oxide + NADP+ + H2O
-
?
L-methionine + NADPH + O2
-
Oryctolagus cuniculus L-methionine S-oxide + NADP+ + H2O
-
?
L-methionine + NADPH + O2 free and N-terminally peptide-bound L-methionine, no activity with modified peptide-bound methionine and with N-acetyl-L-methionine, isozymes FMO1-FMO4 Homo sapiens L-methionine S-oxide + NADP+ + H2O stereospecificity for formation of the D-isomer, especially by isozyme FMO3 ?
L-methionine + NADPH + O2 free and N-terminally peptide-bound L-methionine, no activity with modified peptide-bound methionine and with N-acetyl-L-methionine, isozymes FMO1-FMO4 Rattus norvegicus L-methionine S-oxide + NADP+ + H2O stereospecificity for formation of the D-isomer, especially by isozyme FMO3 ?
L-methionine + NADPH + O2 free and N-terminally peptide-bound L-methionine, no activity with modified peptide-bound methionine and with N-acetyl-L-methionine, isozymes FMO1-FMO4 Oryctolagus cuniculus L-methionine S-oxide + NADP+ + H2O stereospecificity for formation of the D-isomer, especially by isozyme FMO3 ?
L-Phe-Met + NADPH + O2 liver microsomes Oryctolagus cuniculus (L-Met-S-oxide)-Phe + NADP+ + H2O
-
?
L-seleno-methionine + NADPH + O2 liver microsomes Oryctolagus cuniculus L-methionine seleno-oxide + NADP+ + H2O
-
?
L-seleno-methionine + NADPH + O2 purified liver isozymes FMO1 and FMO3 Rattus norvegicus L-methionine seleno-oxide + NADP+ + H2O
-
?
additional information stereoselectivity of male and female liver microsomes, and of recombinant isozymes FMO1, FMO3, and FMO4, overview Homo sapiens ?
-
?
additional information stereoselectivity of purified isozymes FMO1 and FMO3, overview Rattus norvegicus ?
-
?
additional information stereoselectivity of recombinant isozymes FMO1, FMO2, and FMO3 Oryctolagus cuniculus ?
-
?
S-benzyl-L-cysteine + NADPH + O2 isozyme FMO1 Rattus norvegicus S-benzyl-L-cysteine S-oxide + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
FMO
-
Homo sapiens
FMO
-
Rattus norvegicus
FMO
-
Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Rattus norvegicus
37
-
assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4
-
-
Homo sapiens
8.4
-
-
Rattus norvegicus
8.4
-
-
Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
FAD
-
Rattus norvegicus
FAD
-
Oryctolagus cuniculus
NADPH
-
Homo sapiens
NADPH
-
Rattus norvegicus
NADPH
-
Oryctolagus cuniculus