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Literature summary for 1.14.13.8 extracted from

  • Chiba, K.; Kubota, E.; Miyakawa, T.; Kato, Y.; Ishizaki, T.
    Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice (1988), J. Pharmacol. Exp. Ther., 246, 1108-1115.
    View publication on PubMed
Search for more literature for 1.14.13.8

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
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 Mus musculus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2 Mus musculus reaction in microsomal detoxification pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a neurotoxin to nigrostriatal dopaminergic neurons 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
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 ?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2 Mus musculus C-57 BL reaction in microsomal detoxification pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a neurotoxin to nigrostriatal dopaminergic neurons 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Mus musculus C-57 BL
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-
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
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 Mus musculus
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liver predominantly Mus musculus
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lung
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 Mus musculus
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additional information not activity in brain A Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2
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 Mus musculus 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
-
 ?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2 reaction in microsomal detoxification pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a neurotoxin to nigrostriatal dopaminergic neurons Mus musculus 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
-
 ?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2
-
 Mus musculus C-57 BL 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
-
 ?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2 reaction in microsomal detoxification pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a neurotoxin to nigrostriatal dopaminergic neurons Mus musculus C-57 BL 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
flavin flavoprotein Mus musculus