Literature summary for 1.14.13.39 extracted from

Grassi, D.; Lagunas, N.; Pinos, H.; Panzica, G.; Garcia-Segura, L.M.; Collado, P.
NADPH-Diaphorase colocalizes with GPER and is modulated by the GPER agonist G1 in the supraoptic and paraventricular nuclei of ovariectomized female rats (2017), Neuroendocrinology, 104, 94-104 .

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Expression

Organism	Comment	Expression
Rattus norvegicus	treatment with a selective G protein-coupled ER agonist decreases NADPH-diaphorase expression in the supraoptic and paraventricular nuclei of the hypothalamus. Treatment with the selective G protein-coupled estrogen receptor agonist in combination with an antagonist effectively rescues the decrease in NADPH-diaphorase expression in both brain regions	additional information

General Information

General Information	Comment	Organism
metabolism	activation of G protein-coupled estrogen receptor in the supraoptic and paraventricular nuclei of the hypothalamus inhibits the phosphorylation of ERK 1/2, which induces a decrease in NADPH-diaphorase expression	Rattus norvegicus

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Release 2023.1 (January 2023)