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Literature summary for 1.14.13.39 extracted from

  • Serfozo, Z.; Kiss, P.; Kukor, Z.; Lontay, B.; Palatka, K.; Varga, V.; Erdodi, F.; Elekes, K.
    Thyroid hormones affect the level and activity of nitric oxide synthase in rat cerebral cortex during postnatal development (2008), Neurochem. Res., 33, 569-578.
    View publication on PubMed
Search for more literature for 1.14.13.39

Activating Compound

Activating Compound Comment Organism Structure
thyroxin 0.001 mg thyroxin significantly increases nNOS activity and nNOS protein level to 153% compared to control Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
6-n-propyl-2-thyouracil 0.1 mg 6-n-propyl-2-thyouracil decreases nNOS activity to 45% compared to control Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P29476
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
 Rattus norvegicus 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
 ?

Synonyms

Synonyms Comment Organism
neuronal nitric oxide synthase
-
 Rattus norvegicus
nNOS
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
5,6,7,8-tetrahydro-L-biopterin
-
 Rattus norvegicus
Calmodulin
-
 Rattus norvegicus
NADPH
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus 0.1 mg 6-n-propyl-2-thyouracil decreases nNOS protein level to 19% compared to control down
Rattus norvegicus 0.001 mg thyroxin significantly increases nNOS protein level to 178% compared to control up