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Literature summary for 1.14.13.39 extracted from

  • Mikula, I.; Durocher, S.; Martasek, P.; Mutus, B.; Slama-Schwok, A.
    Isoform-specific differences in the nitrite reductase activity of nitric oxide synthases under hypoxia (2009), Biochem. J., 418, 673-682.
    View publication on PubMed
Search for more literature for 1.14.13.39

Inhibitors

Inhibitors Comment Organism Structure
3-bromo-7-nitroindazole nNOS-specific inhibitor, complete inhibition at 0.01 mM Homo sapiens
L-N-methylarginine NOS inhibitor, complete inhibition at 0.5 mM; NOS inhibitor, complete inhibition at 0.5 mM; NOS inhibitor, complete inhibition at 0.5 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P29474
-
-
Homo sapiens P29475
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dermal microvascular endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
 Homo sapiens 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
 ?
additional information NOS has also nitrite reductase activity, the release of free nitric oxide from anoxic nitrite solutions at 0.015 mM is specific to the eNOS isoform and does not occur with the nNOS or iNOS isoforms Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
endothelial NOS isoform Homo sapiens
eNOS
-
 Homo sapiens
inducible NOS isoform Homo sapiens
iNOS
-
 Homo sapiens
neuronal NOS isoform Homo sapiens
nNOS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
(6R)-5,6,7,8-tetrahydro-L-biopterin
-
 Homo sapiens
Calmodulin
-
 Homo sapiens
NADPH
-
 Homo sapiens