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Literature summary for 1.14.13.32 extracted from
- Absorption and metabolism of albendazole after intestinal ischemia/reperfusion (2007), Eur. J. Pharm. Sci., 31, 16-24.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0198 | - |
albendazole | - |
Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| albendazole + NADPH + H+ + O2 | Rattus norvegicus | - |
albendazole S-oxide + NADP+ + H2O | - |
? | |
| additional information | Rattus norvegicus | intestinal bioconversion of the anthelmintic drug albendazole into albendazole sulfoxide by two enzymatic systems, cytochrome P4503A and flavin-containing monooxygenases, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ileum | - |
Rattus norvegicus | - |
| intestine | - |
Rattus norvegicus | - |
| jejunum | - |
Rattus norvegicus | - |
| additional information | in situ enzyme assays, histochemic analysis, overview | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
in situ activity in the intestine | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| albendazole + NADPH + H+ + O2 | - |
Rattus norvegicus | albendazole S-oxide + NADP+ + H2O | - |
? | |
| additional information | intestinal bioconversion of the anthelmintic drug albendazole into albendazole sulfoxide by two enzymatic systems, cytochrome P4503A and flavin-containing monooxygenases, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| albendazol sulfoxidase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Rattus norvegicus | |
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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