Literature summary for 1.14.13.234 extracted from

Herbst, E.; Lee, A.; Tang, Y.; Snyder, S.; Cornish, V.
Heterologous catalysis of the final steps of tetracycline biosynthesis by Saccharomyces cerevisiae (2021), ACS Chem. Biol., 16, 1425-1434 .

Search for more literature for 1.14.13.234

Application

Application	Comment	Organism
synthesis	biosynthesis of tetracycline from anhydrotetracycline in Saccharomyces cerevisiae heterologously expressing the anhydrotetracycline hydroxylase OxyS, the dehydrotetracycline reductase CtcM, and the F420 reductase FNO from three bacterial hosts. This biosynthesis of tetracycline is enabled by OxyS performing just one hydroxylation step in S. cerevisiae	Streptomyces rimosus subsp. rimosus

Organism

Organism	UniProt	Comment	Textmining
Streptomyces rimosus subsp. rimosus	L8EUQ6	cf. EC 1.14.13.38	-
Streptomyces rimosus subsp. rimosus DSM 40260	L8EUQ6	cf. EC 1.14.13.38	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
anhydrotetracycline + NADPH + H+ + O2	-	Streptomyces rimosus subsp. rimosus	5a,11a-dehydrotetracycline + NADP+ + H2O	-	?
anhydrotetracycline + NADPH + H+ + O2	-	Streptomyces rimosus subsp. rimosus DSM 40260	5a,11a-dehydrotetracycline + NADP+ + H2O	-	?

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Release 2023.1 (January 2023)