Literature summary for 1.14.13.229 extracted from

Schuster, J.; Schaefer, F.; Huebler, N.; Brandt, A.; Rosell, M.; Haertig, C.; Harms, H.; Mueller, R.H.; Rohwerder, T.
Bacterial degradation of tert-amyl alcohol proceeds via hemiterpene 2-methyl-3-buten-2-ol by employing the tertiary alcohol desaturase function of the Rieske nonheme mononuclear iron oxygenase MdpJ (2012), J. Bacteriol., 194, 972-981.

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Organism

Organism	UniProt	Comment	Textmining
Aquincola tertiaricarbonis	G8FRC5	-	-
Aquincola tertiaricarbonis L108	G8FRC5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
tert-butyl alcohol + NADPH + H+ + O2	-	Aquincola tertiaricarbonis	2-methylpropan-1,2-diol + NADP+ + 2 H2O	product is further metabolized to 2-hydroxyisobutanoate	?
tert-butyl alcohol + NADPH + H+ + O2	-	Aquincola tertiaricarbonis L108	2-methylpropan-1,2-diol + NADP+ + 2 H2O	product is further metabolized to 2-hydroxyisobutanoate	?

Synonyms

Synonyms	Comment	Organism
MdpJ	-	Aquincola tertiaricarbonis

General Information

General Information	Comment	Organism
physiological function	MdpJ knockout mutants are not able to grow on the tertiary alcohols tert-butanol and tert-amyl alcohol, whereas 2-methylpropan-1,2-diol, the putative product of tert-butanol hydroxylation by MdpJ catalysis can still be used as the sole source of energy and carbon. The postulated 2-methylpropan-1,2-diol intermediate 2-hydroxyisobutanoate is metabolized by wild-type and mutant strains at the same rates	Aquincola tertiaricarbonis

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Release 2023.1 (January 2023)