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Literature summary for 1.14.13.200 extracted from
- Triple hydroxylation of tetracenomycin A2 to tetracenomycin C involving two molecules of O2 and one molecule of H2O (2000), Org. Lett., 2, 3225-3227.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Streptomyces lividans 1326 | Streptomyces glaucescens |
| expression in Streptomyces lividans 1326 | Streptomyces olivaceus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces glaucescens | - |
- |
- |
| Streptomyces olivaceus | Q9L4Y1 | - |
- |
| Streptomyces olivaceus Tue2353 | Q9L4Y1 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ = tetracenomycin C + 2 NAD(P)+ + H2O | reaction proceeds via a monooxygenase-dioxygenase mechanism, deriving the 4- and 12a-OH groups of tetracenomycin C from two molecules of O2 and the 4a-OH group of etracenomycin C from a molecule of H2O | Streptomyces glaucescens | |
| tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+ = tetracenomycin C + 2 NAD(P)+ + H2O | reaction proceeds via a monooxygenase-dioxygenase mechanism, deriving the 4- and 12a-OH groups of tetracenomycin C from two molecules of O2 and the 4a-OH group of etracenomycin C from a molecule of H2O | Streptomyces olivaceus |
a
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Release 2023.1 (January 2023)
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