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Literature summary for 1.14.13.154 extracted from
- Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis (1993), J. Bacteriol., 175, 182-189.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Saccharopolyspora erythraea |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43759 | - |
x * 43759, calculated from sequence | Saccharopolyspora erythraea |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharopolyspora erythraea | P48635 | - |
- |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43759, calculated from sequence | Saccharopolyspora erythraea |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EryK | - |
Saccharopolyspora erythraea |
| erythromycin C-12 hydroxylase | - |
Saccharopolyspora erythraea |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P-450 | a heme-thiolate protein (P-450) | Saccharopolyspora erythraea |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | an Saccharopolyspora erythraea strain disrupted in eryK no longer produces erythromycin A but accumulates the B and D forms of the antibiotic | Saccharopolyspora erythraea |
| physiological function | the enzyme is responsible for the C-12 hydroxylation of the macrolactone ring, one of the last steps in erythromycin biosynthesis | Saccharopolyspora erythraea |
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