Cloned (Comment) | Organism |
---|---|
recombinant His-tagged EryK is overexpressed in BL21 STAR (DE3) Escherichia coli strain | Saccharopolyspora erythraea |
Crystallization (Comment) | Organism |
---|---|
crystal structures of EryK in complex with the azole inhibitors ketoconazole and clotrimazole | Saccharopolyspora erythraea |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clotrimazole | induces a distortion of the internal helix I that affects the accessibility of the binding pocket by regulating the kink of the external helix G via a network of interactions that involves helix F | Saccharopolyspora erythraea | |
ketoconazole | induces a distortion of the internal helix I that affects the accessibility of the binding pocket by regulating the kink of the external helix G via a network of interactions that involves helix F | Saccharopolyspora erythraea |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharopolyspora erythraea | P48635 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Saccharopolyspora erythraea |
Synonyms | Comment | Organism |
---|---|---|
EryK | - |
Saccharopolyspora erythraea |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P-450 | a heme-thiolate protein (P-450) | Saccharopolyspora erythraea |