Application | Comment | Organism |
---|---|---|
biotechnology | an antisense suppression approach, repressing the expression of the taxoid 14beta-hydroxlyase gene in yew cell cultures, is useful to inhibit the expression of other important genes in side-route of Taxol pathway and this may diverts the flow of taxadiene mainly towards Taxol | Taxus chinensis |
Cloned (Comment) | Organism |
---|---|
expressed in the Taxus x media TM3 cell line. The expression of endogenous taxoid 14beta-hydroxylase gene is significantly suppressed by the exogenous as taxoid 14beta-hydroxylase gene | Taxus chinensis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taxus chinensis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-hydroxytaxa-4(20),11(12)-diene + O2 + NADPH + H+ | - |
Taxus chinensis | ? + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
taxoid 14beta-hydroxylase | - |
Taxus chinensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | - |
Taxus chinensis |