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Literature summary for 1.14.13.146 extracted from

  • Li, F.; Ma, X.; Hu, X.; Hoffman, A.; Dai, J.; Qiu, D.
    Antisense-induced suppression of taxoid 14beta-hydroxylase gene expression in transgenic Taxus x media cells (2011), Afr. J. Biotechnol., 10, 8720-8728.
No PubMed abstract available

Application

Application Comment Organism
biotechnology an antisense suppression approach, repressing the expression of the taxoid 14beta-hydroxlyase gene in yew cell cultures, is useful to inhibit the expression of other important genes in side-route of Taxol pathway and this may diverts the flow of taxadiene mainly towards Taxol Taxus chinensis

Cloned(Commentary)

Cloned (Comment) Organism
expressed in the Taxus x media TM3 cell line. The expression of endogenous taxoid 14beta-hydroxylase gene is significantly suppressed by the exogenous as taxoid 14beta-hydroxylase gene Taxus chinensis

Organism

Organism UniProt Comment Textmining
Taxus chinensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-hydroxytaxa-4(20),11(12)-diene + O2 + NADPH + H+
-
Taxus chinensis ? + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
taxoid 14beta-hydroxylase
-
Taxus chinensis

Cofactor

Cofactor Comment Organism Structure
cytochrome P450
-
Taxus chinensis