Literature summary for 1.14.12.12 extracted from

Chopard, C.; Bertho, G.; Prange, T.
Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes (2012), RSC Adv., 2, 605-615.

No PubMed abstract available

Search for more literature for 1.14.12.12

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Pseudomonas sp.

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas sp.	-	-	-
Pseudomonas sp. NCIB 9616-4	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-methylquinoline + NADH + H+ + O2	-	Pseudomonas sp.	(5R,6S)-2-methyl-5,6-dihydroquinoline-5,6-diol + 2-methylquinolin-8-ol + NAD+	99% total conversion, giving 92% (5R,6S)-2-methyl-5,6-dihydroquinoline-5,6-diol and 8% 2-methylquinolin-8-ol	?
2-methylquinoline + NADH + H+ + O2	-	Pseudomonas sp. NCIB 9616-4	(5R,6S)-2-methyl-5,6-dihydroquinoline-5,6-diol + 2-methylquinolin-8-ol + NAD+	99% total conversion, giving 92% (5R,6S)-2-methyl-5,6-dihydroquinoline-5,6-diol and 8% 2-methylquinolin-8-ol	?
3-methylisoquinoline + NADH + H+ + O2	-	Pseudomonas sp.	cis-3-methyl-7,8-dihydroisoquinoline-7,8-diol + 3-methylisoquinolin-5-ol + NAD+	99% total conversion, giving 73% cis-3-methyl-7,8-dihydroisoquinoline-7,8-diol + 27% 3-methylisoquinolin-5-ol	?
3-methylisoquinoline + NADH + H+ + O2	-	Pseudomonas sp. NCIB 9616-4	cis-3-methyl-7,8-dihydroisoquinoline-7,8-diol + 3-methylisoquinolin-5-ol + NAD+	99% total conversion, giving 73% cis-3-methyl-7,8-dihydroisoquinoline-7,8-diol + 27% 3-methylisoquinolin-5-ol	?
8-methylquinoline + NADH + H+ + O2	-	Pseudomonas sp.	5,6-dihydroquinolin-8-ylmethanol + (5R,6S)-8-methyl-5,6-dihydroquinoline-5,6-diol + NAD+	78% total conversion, giving 72% 5,6-dihydroquinolin-8-ylmethanol + 28% (5R,6S)-8-methyl-5,6-dihydroquinoline-5,6-diol	?
8-methylquinoline + NADH + H+ + O2	-	Pseudomonas sp. NCIB 9616-4	5,6-dihydroquinolin-8-ylmethanol + (5R,6S)-8-methyl-5,6-dihydroquinoline-5,6-diol + NAD+	78% total conversion, giving 72% 5,6-dihydroquinolin-8-ylmethanol + 28% (5R,6S)-8-methyl-5,6-dihydroquinoline-5,6-diol	?
quinazoline + NADH + H+ + O2	-	Pseudomonas sp.	(5R,6S)-5,6-dihydroquinazoline-5,6-diol + quinazolin-8-ol	99% total conversion, givng 56% (5R,6S)-5,6-dihydroquinazoline-5,6-diol + 43% quinazolin-8-ol	?
quinazoline + NADH + H+ + O2	-	Pseudomonas sp. NCIB 9616-4	(5R,6S)-5,6-dihydroquinazoline-5,6-diol + quinazolin-8-ol	99% total conversion, givng 56% (5R,6S)-5,6-dihydroquinazoline-5,6-diol + 43% quinazolin-8-ol	?
quinoline + NADH + H+ + O2	-	Pseudomonas sp.	(5R,6S)-5,6-dihydroquinoline-5,6-diol + quinolin-3-ol + NAD+	66% total conversion, giving 55% (5R,6S)-5,6-dihydroquinoline-5,6-diol and 35% quinolin-3-ol	?
quinoline + NADH + H+ + O2	-	Pseudomonas sp. NCIB 9616-4	(5R,6S)-5,6-dihydroquinoline-5,6-diol + quinolin-3-ol + NAD+	66% total conversion, giving 55% (5R,6S)-5,6-dihydroquinoline-5,6-diol and 35% quinolin-3-ol	?
quinoxaline + NADH + H+ + O2	-	Pseudomonas sp.	(5R,6S)-5,6-dihydroquinoxaline-5,6-diol + NAD+	exclusive product	?

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Release 2023.1 (January 2023)