Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[procollagen]-L-proline + 2-oxoglutarate + O2 | Homo sapiens | - |
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2 | - |
? | |
[procollagen]-L-proline + 2-oxoglutarate + O2 | Mus musculus | - |
[procollagen]-trans-3-hydroxy-L-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IVL5 | - |
- |
Mus musculus | Q8CG71 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
umbilical vein endothelial cell | - |
Homo sapiens | - |
umbilical vein endothelial cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[procollagen]-L-proline + 2-oxoglutarate + O2 | - |
Homo sapiens | [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2 | - |
? | |
[procollagen]-L-proline + 2-oxoglutarate + O2 | - |
Mus musculus | [procollagen]-trans-3-hydroxy-L-proline + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
P3H2 | - |
Homo sapiens |
P3H2 | - |
Mus musculus |
prolyl 3-hydroxylase 2 | - |
Homo sapiens |
prolyl 3-hydroxylase 2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme could be considered as a potential target for anti-angiogenesis therapy | Homo sapiens |
drug target | the enzyme could be considered as a potential target for anti-angiogenesis therapy | Mus musculus |
physiological function | P3H2 is involved in formation of new vessels. The enzyme catalyzes the post-translational formation of 3-hydroxyproline on collagens, mainly on type IV. Through its activity on type IV collagen, the enzyme is essential for angiogenesis properties of endothelial cells in vitro by performing experiments of gain- and loss-of-function. Overexpression of P3H2 induces a more condensed status of Collagen IV, accompanied by an alignment of the cells along the Collagen IV bundles, so towards an evident pro-angiogenic status | Homo sapiens |
physiological function | P3H2 is involved in formation of new vessels. The enzyme catalyzes the post-translational formation of 3-hydroxyproline on collagens, mainly on type IV. Through its activity on type IV collagen, the enzyme is essential for angiogenesis properties of endothelial cells in vitro by performing experiments of gain- and loss-of-function. Overexpression of P3H2 induces a more condensed status of Collagen IV, accompanied by an alignment of the cells along the Collagen IV bundles, so towards an evident pro-angiogenic status | Mus musculus |