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Literature summary for 1.14.11.6 extracted from

  • Yu, Z.; Genest, P.; ter Riet, B.; Sweeney, K.; DiPaolo, C.; Kieft, R.; Christodoulou, E.; Perrakis, A.; Simmons, J.M.; Hausinger, R.P.; van Luenen, H.G.; Rigden, D.J.; Sabatini, R.; Borst, P.
    The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase (2007), Nucleic Acids Res., 35, 2107-2115.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.6

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, fusion protein with green fluorescent protein and with His-tag Trypanosoma brucei
expression in Escherichia coli, fusion protein with green fluorescent protein and with His-tag Leishmania tarentolae

Protein Variants

Protein Variants Comment Organism
D191A mutation abrogates the ability of JBP1 to complement JBP1 null mutants Trypanosoma brucei
D215S mutant proteins fail to restore the J-level in the JBP1 null trypanosomes to wild-type levels Leishmania tarentolae
H189A mutation abrogates the ability of JBP1 to complement JBP1 null mutants Trypanosoma brucei
H189A/D191A mutation abrogates the ability of JBP1 to complement JBP1 null mutants Trypanosoma brucei
H213S mutant proteins fail to restore the J-level in the JBP1 null trypanosomes to wild-type levels Leishmania tarentolae
H239A mutation abrogates the ability of JBP1 to complement JBP1 null mutants Trypanosoma brucei
R255A mutation abrogates the ability of JBP1 to complement JBP1 null mutants Trypanosoma brucei
V259A mutation abrogates the ability of JBP1 to complement JBP1 null mutants Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Trypanosoma brucei enzyme is responsible for the local amplification of the unusual DNA base J ?
-
 ?
additional information Leishmania tarentolae enzyme is responsible for the local amplification of the unusual DNA base J ?
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania tarentolae
-
-
-
Trypanosoma brucei
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
trypanosomoid form trypanosomatid Trypanosoma brucei
-
trypanosomoid form trypanosomatid Leishmania tarentolae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is responsible for the local amplification of the unusual DNA base J Trypanosoma brucei ?
-
 ?
additional information enzyme is responsible for the local amplification of the unusual DNA base J Leishmania tarentolae ?
-
 ?

Synonyms

Synonyms Comment Organism
J-binding protein 1
-
 Trypanosoma brucei
J-binding protein 1
-
 Leishmania tarentolae
JBP1
-
 Trypanosoma brucei
JBP1
-
 Leishmania tarentolae