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Literature summary for 1.14.11.54 extracted from

  • Dango, S.; Mosammaparast, N.; Sowa, M.E.; Xiong, L.J.; Wu, F.; Park, K.; Rubin, M.; Gygi, S.; Harper, J.W.; Shi, Y.
    DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation (2011), Mol. Cell, 44, 373-384.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q96Q83
-
-

Source Tissue

Source Tissue Comment Organism Textmining
293-T cell
-
 Homo sapiens
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PC-3 cell
-
 Homo sapiens
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General Information

General Information Comment Organism
physiological function ALKBH3 is associated with the activating signal cointegrator complex ASCC. ALKBH3 is overexpressed in various cancers, and both ALKBH3 and ASCC are important for alkylation damage resistance in these tumor cell lines. ASCC3, the largest subunit of ASCC, encodes a 3'-5' DNA helicase, whose activity is crucial for the generation of single-stranded DNA upon which ALKBH3 preferentially functions for dealkylation. In cell lines that are dependent on ALKBH3 and ASCC3 for alkylation damage resistance, loss of ALKBH3 or ASCC3 leads to increased 3-methylcytosine and reduced cell proliferation. ALKBH3 catalytic activity is important for alkylation damage resistance Homo sapiens