Protein Variants | Comment | Organism |
---|---|---|
H231A/D233A | inactive | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme binds preferentially to pre-mRNAs in intronic regions, in the proximity of alternatively spliced exons and poly(A) sites | ? | - |
? | |
N6-methyladenine in mRNA + 2-oxoglutarate + O2 | Homo sapiens | - |
adenine in mRNA + formaldehyde + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme binds preferentially to pre-mRNAs in intronic regions, in the proximity of alternatively spliced exons and poly(A) sites | Homo sapiens | ? | - |
? | |
N6-methyladenine in mRNA + 2-oxoglutarate + O2 | - |
Homo sapiens | adenine in mRNA + formaldehyde + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FTO | - |
Homo sapiens |
m6A mRNA demethylase | - |
Homo sapiens |
N6-methyladenosine demethylase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme triggers inclusion of alternatively spliced exons and regulates expression of last exons | Homo sapiens |