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Literature summary for 1.14.11.53 extracted from

  • Bartosovic, M.; Molares, H.C.; Gregorova, P.; Hrossova, D.; Kudla, G.; Vanacova, S.
    N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3-end processing (2017), Nucleic Acids Res., 45, 11356-11370 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
H231A/D233A inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme binds preferentially to pre-mRNAs in intronic regions, in the proximity of alternatively spliced exons and poly(A) sites ?
-
?
N6-methyladenine in mRNA + 2-oxoglutarate + O2 Homo sapiens
-
adenine in mRNA + formaldehyde + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme binds preferentially to pre-mRNAs in intronic regions, in the proximity of alternatively spliced exons and poly(A) sites Homo sapiens ?
-
?
N6-methyladenine in mRNA + 2-oxoglutarate + O2
-
Homo sapiens adenine in mRNA + formaldehyde + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
FTO
-
Homo sapiens
m6A mRNA demethylase
-
Homo sapiens
N6-methyladenosine demethylase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme triggers inclusion of alternatively spliced exons and regulates expression of last exons Homo sapiens