Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.53 extracted from

  • Ye, F.; Zhang, L.; Jin, L.; Zheng, M.; Jiang, H.; Luo, C.
    Repair of methyl lesions in RNA by oxidative demethylation (2014), MedChemComm, 5, 1797-1803 .
No PubMed abstract available
Search for more literature for 1.14.11.53

Inhibitors

Inhibitors Comment Organism Structure
citrate modest inhibitor of ALKHB5 Homo sapiens
Rhein inhibitor of FTO Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6-methyladenine in mRNA + 2-oxoglutarate + O2 Homo sapiens
-
 adenine in mRNA + formaldehyde + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-methyladenine in mRNA + 2-oxoglutarate + O2
-
 Homo sapiens adenine in mRNA + formaldehyde + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ALKBH5
-
 Homo sapiens
FTO
-
 Homo sapiens
m6A RNA demethylase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme FTO plays a role in human obesity and energy utilization. FTO is involved in various diseases including cardiovascular diseases,Alzheimer's disease, type II diabetes, breast cancer, and end-stage renal disease. The enzyme ALKHB5 is involoved in sperm development Homo sapiens