Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.53 extracted from

  • Huang, Y.; Yan, J.; Li, Q.; Li, J.; Gong, S.; Zhou, H.; Gan, J.; Jiang, H.; Jia, G.F.; Luo, C.; Yang, C.G.
    Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5 (2015), Nucleic Acids Res., 43, 373-384.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by meclofenamic acid Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6-methyladenine in mRNA + 2-oxoglutarate + O2 Homo sapiens
-
adenine in mRNA + formaldehyde + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6P6C2
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-CUCGAUACG(m6A)UCCGGUCAAA-3' + 2-oxoglutarate + O2
-
Homo sapiens 5'-CUCGAUACGAUCCGGUCAAA-3' + formaldehyde + succinate + CO2
-
?
N6-methyladenine in mRNA + 2-oxoglutarate + O2
-
Homo sapiens adenine in mRNA + formaldehyde + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
ALKBH5
-
Homo sapiens