Cloned (Comment) | Organism |
---|---|
gene PLOD2, DNA and amino acid sequence determination and analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | identification of a PLOD2 mutant bearing 2 missense mutations in exon 17 in patients with Buck syndrome caused by a pyrolidine deficiency in bone due to decreased enzyme activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-lysine + 2-oxoglutarate + O2 | Homo sapiens | enzyme is important in fibrosis because its hydroxylation activity of lysine residues in telopeptides leads to increased cross-linking of accumulated collagen with pyrolidine in fibrotic tissues, enzyme expression in increased in systemic sclerosis | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00469 | isozyme LH2, gene PLOD2; gene PLOD2 encoding isozyme LH2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | from fibrotic skin of patients with systemic sclerosis | Homo sapiens | - |
skin | fibrotic skin from patients with systemic sclerosis | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-lysine + 2-oxoglutarate + O2 | - |
Homo sapiens | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
procollagen L-lysine + 2-oxoglutarate + O2 | enzyme is important in fibrosis because its hydroxylation activity of lysine residues in telopeptides leads to increased cross-linking of accumulated collagen with pyrolidine in fibrotic tissues, enzyme expression in increased in systemic sclerosis | Homo sapiens | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LH2 | - |
Homo sapiens |
lysyl hydroxylase | - |
Homo sapiens |
telopeptide lysyl hydroxylase | - |
Homo sapiens |
TLH | - |
Homo sapiens |