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Literature summary for 1.14.11.4 extracted from
- Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes (1982), Methods Enzymol., 82, 245-304.
General Stability
| General Stability | Organism |
|---|---|
| inactivation by freezing/thawing | Gallus gallus |
| inactivation by freezing/thawing | Homo sapiens |
| labile in tissue extracts | Gallus gallus |
| labile in tissue extracts | Homo sapiens |
| loss of activity during concentration | Gallus gallus |
| loss of activity during concentration | Homo sapiens |
| stabilization by detergents, NaCl | Gallus gallus |
| stabilization by detergents, NaCl | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.4 | 0.5 | Procollagen L-lysine | - |
Gallus gallus |  |
| 0.4 | 0.5 | Procollagen L-lysine | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Gallus gallus | 5783 | - |
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | - |
Gallus gallus | |
| Fe2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 200000 | - |
- |
Gallus gallus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Gallus gallus |
| glycoprotein | - |
Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Gallus gallus | - |
| embryo | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay methods | Gallus gallus |
| additional information | - |
assay methods | Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C | Gallus gallus |
| -20°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidyl-L-lysine + 2-oxoglutarate + O2 | minimum sequence required: Xaa-Lys-Gly | Gallus gallus | peptidyl-5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
| peptidyl-L-lysine + 2-oxoglutarate + O2 | minimum sequence required: Xaa-Lys-Gly | Homo sapiens | peptidyl-5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
| [procollagen] L-lysine + 2-oxoglutarate + O2 | - |
Gallus gallus | [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
r | |
| [procollagen] L-lysine + 2-oxoglutarate + O2 | - |
Homo sapiens | [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2 | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Gallus gallus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Gallus gallus | |
| additional information | - |
additional information | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Gallus gallus |
| 7.4 | - |
- |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ascorbate | - |
Gallus gallus | |
| ascorbate | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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