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Literature summary for 1.14.11.33 extracted from

  • Chen, F.; Tang, Q.; Bian, K.; Humulock, Z.; Yang, X.; Jost, M.; Drennan, C.; Essigmann, J.; Li, D.
    Adaptive response enzyme AlkB preferentially repairs 1-methylguanine and 3-methylthymine adducts in double-stranded DNA (2016), Chem. Res. Toxicol., 29, 687-693.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information AlkB prefers to repair N1-methylguanine and N3-methylthymine lesions in ds-DNA over ss-DNA. The enzyme is able to repair the lesion when the adduct is present in a mismatched base pair Escherichia coli ?
-
 ?
N1-methyladenine in DNA + 2-oxoglutarate + O2 strong substrate in ss-DNA Escherichia coli adenine in DNA + formaldehyde + succinate + CO2
-
 ?
N1-methylguanine in DNA + 2-oxoglutarate + O2 weak substrate in ds-DNA Escherichia coli guanine in DNA + formaldehyde + succinate + CO2
-
 ?
N3-methylcytosine in DNA + 2-oxoglutarate + O2 strong substrate in ss-DNA Escherichia coli cytosine in DNA + formaldehyde + succinate + CO2
-
 ?
N3-methylthymine in DNA + 2-oxoglutarate + O2 weak substrate in ds-DNA Escherichia coli thymine in DNA + formaldehyde + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
AlkB
-
 Escherichia coli