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Literature summary for 1.14.11.33 extracted from

  • Falnes, P.O.
    Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins (2004), Nucleic Acids Res., 32, 6260-6267.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.33

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for activity Escherichia coli
Fe2+ required for activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-1-methyladenine + 2-oxoglutarate + O2
-
 Escherichia coli DNA-adenine + formaldehyde + succinate + CO2
-
 ?
DNA-1-methyladenine + 2-oxoglutarate + O2
-
 Homo sapiens DNA-adenine + formaldehyde + succinate + CO2
-
 ?
DNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Escherichia coli DNA-cytosine + formaldehyde + succinate + CO2
-
 ?
DNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Homo sapiens DNA-cytosine + formaldehyde + succinate + CO2
-
 ?
DNA-3-methylthymine + 2-oxoglutarate + O2
-
 Escherichia coli DNA-thymine + formaldehyde + succinate + CO2
-
 ?
DNA-3-methylthymine + 2-oxoglutarate + O2
-
 Homo sapiens DNA-thymine + formaldehyde + succinate + CO2
-
 ?
additional information adenosine, deoxythymine, 3-methyldeoxythymidine, guanosine, 1-methylguanosine, 1-methylguanine and 3-methylthymine do not stimulate AlkB-mediated decarboxylation of 2-oxoglutarate Escherichia coli ?
-
 ?
RNA-1-methyladenine + 2-oxoglutarate + O2
-
 Escherichia coli RNA-adenine + formaldehyde + succinate + CO2
-
 ?
RNA-1-methyladenine + 2-oxoglutarate + O2
-
 Homo sapiens RNA-adenine + formaldehyde + succinate + CO2
-
 ?
RNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Escherichia coli RNA-cytosine + formaldehyde + succinate + CO2
-
 ?
RNA-3-methylcytosine + 2-oxoglutarate + O2
-
 Homo sapiens RNA-cytosine + formaldehyde + succinate + CO2
-
 ?
tRNA-1-methylguanine + 2-oxoglutarate + O2
-
 Escherichia coli tRNA-guanine + formaldehyde + succinate + CO2
-
 ?
tRNA-1-methylguanine + 2-oxoglutarate + O2
-
 Homo sapiens tRNA-guanine + formaldehyde + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ABH2 isoform Homo sapiens
ABH3 isoform Homo sapiens
AlkB
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
2-oxoglutarate
-
 Escherichia coli
2-oxoglutarate
-
 Homo sapiens