Crystallization (Comment) | Organism |
---|---|
formation of an Fe-Cl cofactor structure in variant D201G. The variant binds Fe with a His2Cl facial triad and activates O2 only in the presence of specific anions. A full His2X triad is an absolute requirement for O2 activation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D201G | removal of the Asp ligand in the His2Asp facial triad, leads to a highly active enzyme. The variant supports anion dependent peptide hydroxylation, exogenous ligand binding to form a complete His2X facial triad is essential for O2 activation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NWT6 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
factor-inhibiting hypoxia inducible factor | - |
Homo sapiens |