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Literature summary for 1.14.11.30 extracted from

  • Jin, P.; Kang, J.; Lee, M.K.; Park, J.W.
    Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH (2018), Biochem. Biophys. Res. Commun., 499, 475-481 .
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
ferritin heavy chain i.e. FTH1, directly activates FIH to hydroxylate HIF-1alpha to ensure its normoxic inactivation. In iron-rich conditions, the transcriptional activity of HIF-1alpha is also inhibited due to forceful induction of FTH1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NWT6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
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HEK-293T cell
-
 Homo sapiens
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SW-480 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
HIF1AN
-
 Homo sapiens
hypoxia-inducible factor 1-alpha inhibitor
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function ferritin heavy chain FTH1 directly interacts with FIH. FTH1 facilitates the FIH-mediated Asn803 hydroxylation in hypoxia-inducible factor HIF-1alpha and prevents the recruitment of p300 to HIF-1alpha through the Asn803 hydroxylation. FTH1 represses the transcriptional activity of HIF-1alpha in HCT-116 cells under either normoxic or hypoxic conditions and downregulates the expression of the HIF-1 target genes Homo sapiens