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Literature summary for 1.14.11.30 extracted from

  • Pelletier, J.; Dayan, F.; Durivault, J.; Ilc, K.; Pecou, E.; Pouyssegur, J.; Mazure, N.M.
    The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53-p21 axis (2012), Oncogene, 31, 2989-3001.
    View publication on PubMed
Search for more literature for 1.14.11.30

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 Homo sapiens
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 hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 gene fih
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Source Tissue

Source Tissue Comment Organism Textmining
A-375 cell melanoma cells Homo sapiens
-
LS-174T cell colon adenocarcinoma cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2
-
 Homo sapiens hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
asparaginyl hydroxylase
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 Homo sapiens
factor-inhibiting HIF
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 Homo sapiens
factor-inhibiting hypoxia-inducible factor
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 Homo sapiens
FIH
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction FIH silencing leads to spacial displacement of the expression pattern of HIF target genes that depend on the C-TAD, such as carbonic anhydrase IX, to more oxygenated areas, whereas overexpression of FIH restricts this pattern to more hypoxic areas. Silencing of gene fih severely reduced in vitro cell proliferation and in vivo tumor growth of LS174 colon adenocarcinoma and A375 melanoma cells. Silencing of fih also significantly increases both the total and phosphorylated forms of the tumor suppressor p53, leading to an increase in its direct target, the cell cycle inhibitor p21. p53-deficient or mutant cells are totally insensitive to FIH expression. FIH activity is essential for tumor growth through the suppression of the p53-p21 axis, the major barrier that prevents cancer progression Homo sapiens
physiological function FIH modulates the profile of hypoxia-inducible factor downstream genes and of hypoxia-inducible factor target genes in a physiological oxygen gradient: the in vitro spheroid model, overview. FIH enhances tumorigenesis and controls in vitro p53 expression. Factor-inhibiting hypoxia-inducible factor monitors the expression of a spectrum of genes that are dictated by the cell's partial oxygen pressure. This action is mediated by the C-TAD, one of two transactivation domains of the hypoxia-inducible factor Homo sapiens