Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 | Homo sapiens | FIH hydroxylates at the asparaginyl residue in the FIH transcriptional activation domain C-TAD | hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 | - |
Homo sapiens | hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2 | - |
? | |
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 | FIH hydroxylates at the asparaginyl residue in the FIH transcriptional activation domain C-TAD | Homo sapiens | hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
factor inhibiting HIF-1 | - |
Homo sapiens |
FIH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | HIF transcriptional activity is controlled by the asparaginyl hydroxylase factor inhibiting HIF-1. Hypoxia-induced HIF signalling, mathematical modelling of the pathway, temporal dynamics of the HIF response to hypoxia, and molecular interaction map for the HIF network, overview. The hypoxia inducible factor is switched on and promotes adaptation to hypoxia by upregulating genes involved in angiogenesis, erythropoiesis and glycolysis | Homo sapiens |
additional information | PHD, EC 1.14.11.29, has a higher affinity for oxygen than FIH | Homo sapiens |
physiological function | HIF transcriptional activity is controlled by the asparaginyl hydroxylase factor inhibiting HIF-1 | Homo sapiens |