Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.30 extracted from

  • Cavadas, M.A.; Nguyen, L.K.; Cheong, A.
    Hypoxia-inducible factor (HIF) network: insights from mathematical models (2013), Cell Commun. Signal., 11, 42.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 Homo sapiens FIH hydroxylates at the asparaginyl residue in the FIH transcriptional activation domain C-TAD hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2
-
Homo sapiens hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
-
?
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 FIH hydroxylates at the asparaginyl residue in the FIH transcriptional activation domain C-TAD Homo sapiens hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
factor inhibiting HIF-1
-
Homo sapiens
FIH
-
Homo sapiens

General Information

General Information Comment Organism
metabolism HIF transcriptional activity is controlled by the asparaginyl hydroxylase factor inhibiting HIF-1. Hypoxia-induced HIF signalling, mathematical modelling of the pathway, temporal dynamics of the HIF response to hypoxia, and molecular interaction map for the HIF network, overview. The hypoxia inducible factor is switched on and promotes adaptation to hypoxia by upregulating genes involved in angiogenesis, erythropoiesis and glycolysis Homo sapiens
additional information PHD, EC 1.14.11.29, has a higher affinity for oxygen than FIH Homo sapiens
physiological function HIF transcriptional activity is controlled by the asparaginyl hydroxylase factor inhibiting HIF-1 Homo sapiens