Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NHM5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
serum response factor N6-methyl-L-lysine165 + 2-oxoglutarate + O2 | - |
Homo sapiens | serum response factor L-lysine165 + succinate + formaldehyde + CO2 | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | KDM2B demethylates serum response factor residue K165 to negatively regulate muscle differentiation. KDM2B inhibits skeletal muscle differentiation by inhibiting the transcription of SRF-dependent genes. Both KDM2B and histone methyltransferase SET7 regulate the balance of SRF K165 methylation. SRF K165 methylation is required for the transcriptional activation of SRF and for the promoter occupancy of SRF-dependent genes | Homo sapiens |