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Literature summary for 1.14.11.27 extracted from

  • Pfau, R.; Tzatsos, A.; Kampranis, S.C.; Serebrennikova, O.B.; Bear, S.E.; Tsichlis, P.N.
    Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process (2008), Proc. Natl. Acad. Sci. USA, 105, 1907-1912.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in mouse embryo fibroblast Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information expression of histone demthylase Ndy1 in mouse embryo fibroblast results in immortalization in absence of replicative senescence via a JmjC domain-dependent process that targets the Rb and p53 pathways. Knockdown of endogenous Ndy1 or expression of JmjC domain mutants of Ndy1 promote senescence, suggesting that Ndy1 is a physiological inhibitor of senescence in dividing cells and that inhibition of senescence depends on histone H3 demethylation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus Ndy1 is a physiological inhibitor of senescence in dividing cells and inhibition of senescence depends on histone H3 demethylation ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 histone demethylases Ndy1
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Source Tissue

Source Tissue Comment Organism Textmining
lymphoma cell
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Ndy1 is a physiological inhibitor of senescence in dividing cells and inhibition of senescence depends on histone H3 demethylation Rattus norvegicus ?
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 ?