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Literature summary for 1.14.11.20 extracted from

  • Guirimand, G.; Guihur, A.; Poutrain, P.; Hericourt, F.; Mahroug, S.; St-Pierre, B.; Burlat, V.; Courdavault, V.
    Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus (2010), J. Plant Physiol., 168, 549-557.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information vindoline biosynthesis pathway enzyme subcellular localization study, overview Catharanthus roseus
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nucleoplasm the enzyme resides in the nucleocytoplasmic compartment following passive diffusion to the nucleus allowed by the protein size. Colocalization with deacetylvindoline-4-O-acetyltransferase Catharanthus roseus 5654
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deacetoxyvindoline + 2-oxoglutarate + O2 Catharanthus roseus
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deacetylvindoline + succinate + CO2
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?
additional information Catharanthus roseus the desacetoxyvindoline-4-hydroxylase interacts with the deacetylvindoline-4-O-acetyltransferase, analysis via yeast two-hybrid system ?
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?

Organism

Organism UniProt Comment Textmining
Catharanthus roseus
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Source Tissue

Source Tissue Comment Organism Textmining
idioblast
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Catharanthus roseus
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laticifer
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Catharanthus roseus
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leaf
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Catharanthus roseus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deacetoxyvindoline + 2-oxoglutarate + O2
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Catharanthus roseus deacetylvindoline + succinate + CO2
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?
additional information the desacetoxyvindoline-4-hydroxylase interacts with the deacetylvindoline-4-O-acetyltransferase, analysis via yeast two-hybrid system Catharanthus roseus ?
-
?

Subunits

Subunits Comment Organism
monomer
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Catharanthus roseus

Synonyms

Synonyms Comment Organism
D4H
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Catharanthus roseus
desacetoxyvindoline-4-hydroxylase
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Catharanthus roseus

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the penultimate step in the biosynthesis of vindoline, which constitutes the main terpenoid indole alkaloid accumulated in leaves of Catharanthus roseus, spatial organization of the vindoline biosynthetic pathway, overview. The desacetoxyvindoline-4-hydroxylase interacts directly with the deacetylvindoline-4-O-acetyltransferase, that catalyzes the last step of the biosynthetic pathway, absence of metabolic channeling in the vindoline biosynthetic pathway. Importance of inter- and intracellular translocations of intermediates during the vindoline biosynthesis and potential regulatory role, overview Catharanthus roseus