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Literature summary for 1.14.11.2 extracted from

  • Konkina, A.; Klepadlo, M.; Lakehal, A.; Zein, Z.E.; Krokida, A.; Botros, M.; Iakovidis, M.; Chernobavskiy, P.; Elfatih Zerroumda, M.; Tsanakas, G.; Petrakis, N.; Dourou, A.M.; Kalaitzis, P.
    An Arabidopsis prolyl 4-hydroxylase is involved in the low oxygen response (2021), Front. Plant Sci., 12, 637352 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 Arabidopsis thaliana
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9LN20
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2
-
 Arabidopsis thaliana procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
P4H
-
 Arabidopsis thaliana
prolyl-4-hydroxylases
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction an Arabidopsis AtP4H3 T-DNA knock out mutant line shows higher sensitivity to anoxic treatment possibly due to lower induction of the fermentation pathway genes, ADH and PDC1, and of sucrose synthases, SUS1 and SUS4. This sensitivity to anoxia is accompanied by lower protein levels of AGPs-bound epitopes such as LM14 in the mutant line and induction of extensins-bound epitopes, while the expression levels of the majority of the AGPs genes are stable throughout a low oxygen time course. The lower AGPs content might be related to altered frequency of proline hydroxylation occurrence in the p4h3 line Arabidopsis thaliana