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Literature summary for 1.14.11.2 extracted from

  • Song, D.; Li, L.S.; Heaton-Johnson, K.J.; Arsenault, P.R.; Master, S.R.; Lee, F.S.
    Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway (2013), J. Biol. Chem., 288, 9662-9674.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
a human embryonic kidney (HEK) 293 cell line is generated expressing FLAG-tagged PHD2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the heat shock protein 90 (HSP90) co-chaperones p23 and FKBP38 interact via a conserved Pro-Xaa-Leu-Glu motif in these proteins with the N-terminal Myeloid Nervy and DEAF-1 (MYND)-type zinc finger of PHD2 ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the heat shock protein 90 (HSP90) co-chaperones p23 and FKBP38 interact via a conserved Pro-Xaa-Leu-Glu motif in these proteins with the N-terminal Myeloid Nervy and DEAF-1 (MYND)-type zinc finger of PHD2 Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
PHD2
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 Homo sapiens
prolyl hydroxylase domain protein 2
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 Homo sapiens

General Information

General Information Comment Organism
physiological function p23 recruits PHD2 to the HSP90 machinery to facilitate HIF-1hydroxylation Homo sapiens