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Literature summary for 1.14.11.2 extracted from

  • Spinella, F.; Rosano, L.; Del Duca, M.; Di Castro, V.; Nicotra, M.R.; Natali, P.G.; Bagnato, A.
    Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells (2010), PLoS ONE, 5, e11241.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.2

Inhibitors

Inhibitors Comment Organism Structure
deferoxamine mesylate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
M10 cell a melanoma cell line Homo sapiens
-
M14 cell a melanoma cell line Homo sapiens
-
Mel120 cell a melanoma cell line Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
melanoma cell line derived from primary melanoma Homo sapiens
-
SK-MEL-28 cell a melanoma cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
prolyl hydroxylase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens endothelin-1 inhibits PHD2 expression and promoter activity by 50% to stabilize HIF-alpha. HIF-1alpha and HIF-2alpha accumulation in response to endothelins is specifically impaired in PHD2 overexpressing cells, indicating that re-expression of PHD2 is sufficient to counteract the ET-1- or ET-3-induced HIF-alpha expression down

General Information

General Information Comment Organism
additional information Endothelin signalling implies HIF-alpha-dependent angiogenesis and tumor cell invasion through PHD2 inhibition in normoxic conditions. Endothelin-1 inhibits PHD2 expression and promoter activity to stabilize HIF-alpha. HIF-1alpha and HIF-2alpha accumulation in response to endothelins is specifically impaired in PHD2 overexpressing cells, indicating that re-expression of PHD2 is sufficient to counteract the ET-1- or ET-3-induced HIF-alpha expression. Knockdown of PHD2 by inhibiting the prolyl hydroxylases with deferoxamine mesylate results in a strong induction of HIF-alpha and VEGF expression Homo sapiens