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Literature summary for 1.14.11.2 extracted from

  • Tennant, D.A.; Gottlieb, E.
    HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression (2010), J. Mol. Med., 88, 839-849.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ascorbate PHD activity requires iron and ascorbate as cofactors Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information stable knockdown of PHDs in A375 cells does not affect cell proliferation, overview. Sections from PHD3 knockdown xenografts show little increase in cleaved caspase-3 staining after treatment with 2-oxoglutarate Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ PHD activity requires iron and ascorbate as cofactors Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-375 cell
-
Homo sapiens
-
A-431 cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2
-
Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
PHD1
-
Homo sapiens
PHD2
-
Homo sapiens
PHD3
-
Homo sapiens
prolyl hydroxylase-3
-
Homo sapiens

General Information

General Information Comment Organism
additional information 2-oxoglutarate-mediated activation of PHD3 is required for tumor suppression, while PHD2 and HIF1alpha are not required, 2-oxoglutarate does not significantly inhibit tumor growth in PHD3 knockdown xenograft tumors. Reactivating PHD2 in A375 cells has no long-term role in inhibiting tumor growth Homo sapiens
physiological function PHD2 is the major regulator of HIF1alpha stability Homo sapiens