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Literature summary for 1.14.11.2 extracted from
- Isolation of Xenopus HIF-prolyl 4-hydroxylase and rescue of a small-eye phenotype caused by Siah2 over-expression (2007), Biochem. Biophys. Res. Commun., 355, 419-425.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 27900 | - |
x * 27900, calculated | Xenopus laevis |
| 45300 | - |
x * 45300, calculated | Xenopus laevis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Xenopus laevis | Q6DFD1 | isoform PHD45 | - |
| Xenopus laevis | Q6DFD1 | isoforms PHD28 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | in embryonic development, isoform PHD45 expression is complementary to that of PHD28. Hypoxia-inducible factor HIF-1alpha protein level is maximal around stage 20 when expression of PHD45 disappears, while expression of PHD28 reaches a maximum at stage 20. Overexpression of the ubiquitin ligase Seven-in-Absentia homolog Siah2 decreases PHD45, but not PHD28, and causes the small-eye phenotype of Xenopus | Xenopus laevis | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 27900, calculated | Xenopus laevis |
| ? | x * 45300, calculated | Xenopus laevis |
| More | protein contains MYND-type zinc finger and oxygenase domains | Xenopus laevis |
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