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Literature summary for 1.14.11.2 extracted from

  • Myllyharju, J.
    Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis (2003), Matrix Biol., 22, 15-24.
    View publication on PubMed
Search for more literature for 1.14.11.2

Activating Compound

Activating Compound Comment Organism Structure
ascorbate required for activity Drosophila melanogaster
ascorbate required for activity Arabidopsis thaliana
ascorbate required for activity Paramecium bursaria Chlorella virus-1
ascorbate required for activity Homo sapiens
ascorbate required for activity Caenorhabditis elegans

Inhibitors

Inhibitors Comment Organism Structure
poly(L-proline)
-
 Drosophila melanogaster
poly(L-proline)
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
 poly(L-proline) molecular weight 20000-40000 Da Arabidopsis thaliana
0.0004
-
 Fe2+
-
 Paramecium bursaria Chlorella virus-1
0.002
-
 Fe2+
-
 Caenorhabditis elegans
0.002
-
 poly(L-proline) molecular weight 5000-10000 Da Arabidopsis thaliana
0.003
-
 Fe2+
-
 Drosophila melanogaster
0.004
-
 Fe2+
-
 Homo sapiens
0.006
-
 Fe2+
-
 Homo sapiens
0.016
-
 Fe2+
-
 Arabidopsis thaliana
0.018
-
 (L-Pro-L-Pro-Gly)10
-
 Drosophila melanogaster
0.018
-
 (L-Pro-L-Pro-Gly)10
-
 Homo sapiens
0.02
-
 2-oxoglutarate
-
 Paramecium bursaria Chlorella virus-1
0.02
-
 (L-Pro-L-Pro-Gly)10
-
 Caenorhabditis elegans
0.022
-
 2-oxoglutarate
-
 Homo sapiens
0.06
-
 (L-Pro-L-Pro-Gly)10
-
 Arabidopsis thaliana
0.08
-
 2-oxoglutarate
-
 Caenorhabditis elegans
0.084
-
 2-oxoglutarate
-
 Drosophila melanogaster
0.095
-
 (L-Pro-L-Pro-Gly)10
-
 Homo sapiens
0.1
-
 poly(L-proline) molecular weight 20000-40000 Da Paramecium bursaria Chlorella virus-1
0.13
-
 2-oxoglutarate
-
 Arabidopsis thaliana
0.3
-
 ascorbate
-
 Drosophila melanogaster
0.3
-
 ascorbate
-
 Arabidopsis thaliana
0.3
-
 ascorbate
-
 Paramecium bursaria Chlorella virus-1
0.33
-
 ascorbate
-
 Homo sapiens
0.34
-
 ascorbate
-
 Homo sapiens
0.35
-
 ascorbate
-
 Caenorhabditis elegans
2.9
-
 (L-Pro-L-Pro-Gly)10
-
 Paramecium bursaria Chlorella virus-1

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for activity Drosophila melanogaster
Fe2+ required for activity Arabidopsis thaliana
Fe2+ required for activity Paramecium bursaria Chlorella virus-1
Fe2+ required for activity Homo sapiens
Fe2+ required for activity Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 Drosophila melanogaster
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 Arabidopsis thaliana
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 Paramecium bursaria Chlorella virus-1
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 Caenorhabditis elegans
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Caenorhabditis elegans Q20065 alpha-2 subunit
-
Drosophila melanogaster
-
-
-
Homo sapiens O15460 alpha-subunit
-
Homo sapiens P13674 alpha-subunit
-
Paramecium bursaria Chlorella virus-1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Drosophila melanogaster (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Arabidopsis thaliana (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Paramecium bursaria Chlorella virus-1 (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Homo sapiens (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
(L-Pro-L-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Caenorhabditis elegans (L-Pro-L-Pro-Gly)10-trans-4-hydroxy-L-proline + succinate + CO2
-
 r
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Drosophila melanogaster (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Arabidopsis thaliana (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Paramecium bursaria Chlorella virus-1 (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Homo sapiens (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
(Pro-Pro-Gly)10 L-proline + 2-oxoglutarate + O2
-
 Caenorhabditis elegans (Pro-Pro-Gly)10 trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
2-oxoglutarate + O2 + ascorbate
-
 Drosophila melanogaster succinate + dehydroascorbate + CO2 + H2O
-
 ?
2-oxoglutarate + O2 + ascorbate
-
 Arabidopsis thaliana succinate + dehydroascorbate + CO2 + H2O
-
 ?
2-oxoglutarate + O2 + ascorbate
-
 Paramecium bursaria Chlorella virus-1 succinate + dehydroascorbate + CO2 + H2O
-
 ?
2-oxoglutarate + O2 + ascorbate
-
 Homo sapiens succinate + dehydroascorbate + CO2 + H2O
-
 ?
2-oxoglutarate + O2 + ascorbate
-
 Caenorhabditis elegans succinate + dehydroascorbate + CO2 + H2O
-
 ?
poly(L-proline) + 2-oxoglutarate + O2
-
 Paramecium bursaria Chlorella virus-1 poly trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
poly(L-proline) + 2-oxoglutarate + O2
-
 Arabidopsis thaliana poly(trans-4-hydroxy-L-proline) + succinate + CO2
-
 r
procollagen L-proline + 2-oxoglutarate + O2
-
 Drosophila melanogaster procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2
-
 Arabidopsis thaliana procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2
-
 Paramecium bursaria Chlorella virus-1 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2
-
 Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2
-
 Caenorhabditis elegans procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Subunits

Subunits Comment Organism
tetramer
-
 Drosophila melanogaster
tetramer
-
 Arabidopsis thaliana
tetramer
-
 Paramecium bursaria Chlorella virus-1
tetramer
-
 Homo sapiens
tetramer
-
 Caenorhabditis elegans

Synonyms

Synonyms Comment Organism
AT-P4H-1
-
 Arabidopsis thaliana
CePHY-1/PHY-2/PDI2
-
 Caenorhabditis elegans
DmP4H
-
 Drosophila melanogaster
HuPH4-I
-
 Homo sapiens
HuPH4-II
-
 Homo sapiens
PBCV-1 P4H
-
 Paramecium bursaria Chlorella virus-1

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00002
-
 poly(L-proline) molecular weight 20000-40000 Da Homo sapiens
0.0005
-
 poly(L-proline) molecular weight 5000-10000 Da Homo sapiens
0.003
-
 poly(L-proline) molecular weight 20000-40000 Da Drosophila melanogaster
0.018
-
 poly(L-proline) molecular weight 5000-10000 Da Drosophila melanogaster
0.02
-
 poly(L-proline) molecular weight 20000-40000 Da Homo sapiens
0.095
-
 poly(L-proline) molecular weight 5000-10000 Da Homo sapiens