Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q12797 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatoma cell line | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
aspartate beta-hydroxylase | - |
Homo sapiens |
ASPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme can be a potential therapeutic target and a 2nd generation beta-hydroxylase inhibitor is an effective anti-tumor agent against intrahepatic hepatocellular carcinoma growth and progression partially through the induction of cellular senescence | Homo sapiens |
physiological function | aspartate beta-hydroxylase modulates cellular senescence through glycogen synthase kinase 3beta in hepatocellular carcinoma. shRNA-mediated knockdown and CRISPR/Cas9-mediated knockout of aspartate beta-hydroxylase as well as enzymatic inhibition of the enzyme guide human hepatocellular carcinoma cells to undergo cellular senescence. Inhibition of aspartate beta-hydroxylase activity induces senescence as mediated through phosphorylation of GSK3beta. In addition, aspartate beta-hydroxylase binding to GSK3beta inhibits its phosphorylation (inactivation) and thus blocks the signal transduction from its upstream kinases | Homo sapiens |