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Literature summary for 1.14.11.16 extracted from

  • Cockman, M.E.; Lancaster, D.E.; Stolze, I.P.; Hewitson, K.S.; McDonough, M.A.; Coleman, M.L.; Coles, C.H.; Yu, X.; Hay, R.T.; Ley, S.C.; Pugh, C.W.; Oldham, N.J.; Masson, N.; Schofield, C.J.; Ratcliffe, P.J.
    Posttranslational hydroxylation of ankyrin repeats in IkB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) (2006), Proc. Natl. Acad. Sci. USA, 103, 14767-14772.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
dimethyloxalylglycine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His6 affinity chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptide L-asparagine + 2-oxoglutarate + O2
-
Homo sapiens peptide 3-hydroxy-L-asparagine + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
factor inhibiting hypoxia-inducible factor
-
Homo sapiens
FIH
-
Homo sapiens
hypoxia-inducible factor asparaginyl hydroxylase
-
Homo sapiens