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Literature summary for 1.14.11.11 extracted from

  • Palazon, J.; Moyano, E.; Cusido, R.M.; Bonfill, M.; Oksman-Caldentey, K.M.; Pinol, M.T.
    Alkaloid production in Duboisia hybrid hairy roots and plants overexpressing the h6h gene (2003), Plant Sci., 165, 1289-1295.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
the gene encoding hyosyamine 6-hydroxylase is placed under the regulation of the CaMV 35S promoter and introduced into the genome of a scopolamine-rich Duboisia hybrid by a binary vector system using Agrobacterium rhizogenes strain LBA9402. The scopolamine levels in the resulting engineered hairy root lines increases up to three times compared to wild-type hairy roots, but there is no clear increase in the engineered regenerated plants Hyoscyamus niger

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 Hyoscyamus niger
-
scopolamine + succinate + CO2
-
?
L-hyoscyamine + 2-oxoglutarate + O2 Hyoscyamus niger
-
6beta-hydroxyhyoscyamine + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Hyoscyamus niger
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2
-
Hyoscyamus niger scopolamine + succinate + CO2
-
?
L-hyoscyamine + 2-oxoglutarate + O2
-
Hyoscyamus niger 6beta-hydroxyhyoscyamine + succinate + CO2
-
?