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Literature summary for 1.13.99.1 extracted from
- myo-Inositol oxygenase from rat kidneys. I: Purification by affinity chromatography; physical and catalytic properties (1979), Hoppe-Seyler's Z. Physiol. Chem., 360, 507-513.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,4,6-Tripyridyl-(2)-1,3,5-triazine | - |
Rattus norvegicus |  |
| o-phenanthroline | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0095 | - |
O2 | - |
Rattus norvegicus | |
| 45 | - |
myo-inositol | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | iron protein | Rattus norvegicus | |
| Fe2+ | contains iron most probably in divalent form, enzyme consisting of 16 subunits contains 8 iron atoms per molecule | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 17000 | - |
4 * 17000, gel filtration, smallest active unit is tetramer, which is in a pH-dependent equilibrium with species consisting of 8, 12 and 16 subunits | Rattus norvegicus |
| 17000 | - |
8 * 17000, smallest active unit is tetramer, it is in a pH-dependent equilibrium with species consisting of 8, 12 and 16 subunits | Rattus norvegicus |
| 17000 | - |
12 * 17000, smallest active unit is tetramer, it is in a pH-dependent equilibrium with species consisting of 8, 12 and 16 subunits | Rattus norvegicus |
| 17000 | - |
16 * 17000, smallest active unit is tetramer, it is in a pH-dependent equilibrium with species consisting of 8, 12 and 16 subunits | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Oxidation Stability
| Oxidation Stability | Organism |
|---|---|
| Highly unstable in presence of oxygen, in early stages of inactivation: reactivation by reducing agents like NaBH4 | Rattus norvegicus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dodecamer | 12 * 17000, smallest active unit is tetramer, it is in a pH-dependent equilibrium with species consisting of 8, 12 and 16 subunits | Rattus norvegicus |
| hexadecamer | 16 * 17000, smallest active unit is tetramer, it is in a pH-dependent equilibrium with species consisting of 8, 12 and 16 subunits | Rattus norvegicus |
| octamer | 8 * 17000, smallest active unit is tetramer, it is in a pH-dependent equilibrium with species consisting of 8, 12 and 16 subunits | Rattus norvegicus |
| tetramer | 4 * 17000, gel filtration, smallest active unit is tetramer, which is in a pH-dependent equilibrium with species consisting of 8, 12 and 16 subunits | Rattus norvegicus |
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