Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | - |
Mus musculus | 5743 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-beta-carotene + O2 | Mus musculus | - |
all-trans-10'-apo-beta-carotenal + beta-ionone | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q99NF1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
hypothalamus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-beta-carotene + O2 | - |
Mus musculus | all-trans-10'-apo-beta-carotenal + beta-ionone | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BCO2 | - |
Mus musculus |
beta,beta-carotene-9,10-oxygenase 2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | systemic depletion of BCO2 causes increased food intake and impaired hepatic lipid metabolism in mice. Compared to wild-type, BCO2 knockout mice exhibit widespread disruptions in metabolism and metabolite homeostasis, an increase in fasting blood glucose, a decrease in circulating glucagon and leptin, an elevation of plasma interleukin 1 beta and tumor necrosis factor alpha, and impaired AMP activated protein kinase signaling. The global hypothalamic metabolomic results reveal that depletion of BCO2 results in striking metabolic changes, including suppression of long-chain fatty acids transport into mitochondria, inhibition of the metabolism of dipeptides and sulfur-containing amino acids, and stimulation of local oxidative stress and inflammation in the hypothalamus of BCO2 knockout mice. Complex interplay between the hormone signaling and impaired lipid and glucose metabolism seems to account for initiation of oxidative stress, inflammation and eventual metabolic disorders in BCO2 knockout mice. Phenotype, overview | Mus musculus |
physiological function | the enzyme catalyzes the asymmetric cleavage of carotenoids. Enzyme BCO2 exerts its role in hypothalamic nutrient metabolism and feeding behavior. BCO2 regulates hypothalamic mitochondrial function, nutrient metabolism, and local oxidative stress and inflammation | Mus musculus |