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Literature summary for 1.13.11.71 extracted from
- Two carotenoid-oxygenases contribute to mammalian pro-vitamin A metabolism (2013), J. Biol. Chem., 288, 34081-34096.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-cryptoxanthin + O2 | main clevage product is beta-apo-10'-carotenal only small amounts of 3-OH-beta-apocarotenal are formed | Mus musculus | beta-apo-10'-carotenal + ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BCO2 | - |
Mus musculus |
| beta-carotene-9',10'-oxygenase | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
assay at | Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | using BCO2 knock out mice it is shown that BCO2 catalyzes beta-apocarotenoid production in vivo. Bco2-/- mice show a significant hepatic accumulation of beta-cryptoxanthin as compared to Bco1-/- and wild-type mice | Mus musculus |
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Release 2023.1 (January 2023)
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