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Literature summary for 1.13.11.71 extracted from

  • Lobo, G.P.; Isken, A.; Hoff, S.; Babino, D.; von Lintig, J.
    BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway (2012), Development, 139, 2966-2977.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.71

Inhibitors

Inhibitors Comment Organism Structure
4-oxo-N-(4-hydroxyphenyl)-all-trans-retinamide
-
 Danio rerio

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Danio rerio 5739
-

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo bcdo2 is expressed in the developing zebrafish Danio rerio
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-carotene + O2
-
 Homo sapiens 10'-apo-carotenal + beta-ionone
-
 ?
beta-carotene + O2
-
 Danio rerio 10'-apo-carotenal + beta-ionone
-
 ?
canthaxanthin + O2
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Bcdo2
-
 Homo sapiens
Bcdo2
-
 Danio rerio

General Information

General Information Comment Organism
malfunction knockdown of Bcdo2 by siRNA treatment in T47D cells enhances reactive oxygen species production upon carotenoid treatment. Bcdo2 siRNA-treated T47D cells show initiation of apoptosis evidenced by caspase 3 and PARP1 cleavage as established by immunoblot analyses Homo sapiens
malfunction targeted knockdown of BCDO2 results in anemia at larval stages. Marker gene analysis and staining for hemoglobin revealed that erythropoiesis is not impaired but that erythrocytes undergo apoptosis in BCDO2- deficient larvae Danio rerio
physiological function BCDO2 dictates apoptotic responses to carotenoids and synthetic retinoids in human cancer cells Homo sapiens