Crystallization (Comment) | Organism |
---|---|
crystal structure analysis | Klebsiella oxytoca |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | dependent on. Fe2+ transmits electrons from the residues, coordinating it to bound dioxygen and populating its formerly p*-orbital. This leads to dioxygen splitting in the second intermediate and eventual access to the Fe2+-dependent acireductone dioxygenase reaction route | Klebsiella oxytoca |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 | Klebsiella oxytoca | - |
4-(methylthio)-2-oxobutanoate + formate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella oxytoca | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 | - |
Klebsiella oxytoca | 4-(methylthio)-2-oxobutanoate + formate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acireductone dioxygenase | - |
Klebsiella oxytoca |
ARD' | - |
Klebsiella oxytoca |
General Information | Comment | Organism |
---|---|---|
additional information | Fe2+-dependent acireductone dioxygenase passes through an additional split dioxygen intermediate and then proceeds through an epoxy-like transition state with a small activation energy to the two products, crystal structure analysis, structure modeling and molecular simulations of the Fe2+ and Ni2+ enzyme, cf. 1.13.11.53, QM-DMD domain, overview. The ability of Fe2+-dependent acireductone dioxygenase to stabilize an additional intermediate and thus produce the two products is due to the RedOx flexibility of the Fe2+ as compared to the more electron-rich Ni2+ | Klebsiella oxytoca |
physiological function | either facilitates recycling of methionine in living cells or exits this recycling pathway. Fe2+-dependent acireductone dioxygenase produces the 2-oxo acid precursor of methionine and formate | Klebsiella oxytoca |