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Literature summary for 1.13.11.52 extracted from

  • Vottero, E.; Balgi, A.; Woods, K.; Tugendreich, S.; Melese, T.; Andersen, R.J.; Mauk, A.G.; Roberge, M.
    Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast (2006), Biotechnol. J., 1, 282-288.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae tryptophan auxotroph can restore growth in presence of low tryptophan concentrations Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
imidodicarbonimidic diamide, N-methyl-N''-9-phenanthrenyl-, monohydrochloride
-
Homo sapiens
methyl-thiohydantoin-tryptophan limited selectivity towards indoleamine 2,3-dioxygenase Homo sapiens
NSC 401366 competitive with respect to tryptophan Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Trp + O2
-
Homo sapiens formylkynurenine
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0015
-
imidodicarbonimidic diamide, N-methyl-N''-9-phenanthrenyl-, monohydrochloride
-
Homo sapiens