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Literature summary for 1.13.11.52 extracted from

  • Sedlmayr, P.; Semlitsch, M.; Gebru, G.; Karpf, E.; Reich, O.; Tang, T.; Wintersteiger, R.; Takikawa, O.; Dohr, G.
    Expression of indoleamine 2,3-dioxygenase in carcinoma of human endometrium and uterine cervix (2003), Adv. Exp. Med. Biol., 527, 91-95.
    View publication on PubMed
Search for more literature for 1.13.11.52

Application

Application Comment Organism
medicine IDO induces suppression of antitumoral immune response, inhibits tumor cell proliferation by tryptophan depletion Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Trp + O2 Homo sapiens the enzyme inhibits tumor cell proliferation by tryptophan depletion. IDO-induced suppression of antitumoral immune response in both adenocarcinoma and squamous cell carcinoma L-formylkynurenine
-
 ?
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cervical cancer cell line
-
 Homo sapiens
-
cervical carcinoma cell
-
 Homo sapiens
-
endometrioid carcinoma cell epithelium Homo sapiens
-
epithelium of uterine endometrium and cervix Homo sapiens
-
additional information cell in the peritumoral infiltrate of the stroma Homo sapiens
-
stromal cell peritumoral infiltrate Homo sapiens
-
uterine cervix epithelium Homo sapiens
-
uterine endometrium epithelium Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Trp + O2 the enzyme inhibits tumor cell proliferation by tryptophan depletion. IDO-induced suppression of antitumoral immune response in both adenocarcinoma and squamous cell carcinoma Homo sapiens L-formylkynurenine
-
 ?
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO
-
 Homo sapiens
indoleamine 2,3-dioxygenase
-
 Homo sapiens