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Literature summary for 1.13.11.33 extracted from

  • Chabane, N.; Zayed, N.; Benderdour, M.; Martel-Pelletier, J.; Pelletier, J.; Duval, N.; Fahmi, H.
    Human articular chondrocytes express 15-lipoxygenase-1 and -2: Potential role in osteoarthritis (2009), Arthritis Res. Ther., 11, R44.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte express both 15-LOX-1 and -2 Homo sapiens
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Synonyms

Synonyms Comment Organism
15-lipoxygenase-1
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 Homo sapiens
15-lipoxygenase-2
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 Homo sapiens
15-LOX-1
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 Homo sapiens
15-LOX-2
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 Homo sapiens

General Information

General Information Comment Organism
physiological function 15-lipoxygenases may have chondroprotective properties by reducing metalloproteinase-1 and -13 expression. Their respective metabolites, 13(S)-hydroxy octadecadienoic and 15(S)-hydroxyeicosatetraenoic acids, suppress interleukin-1beta-induced metalloproteinase-1 and -13 expression in a PPARgamma-dependent pathway Homo sapiens