Literature summary for 1.13.11.33 extracted from

Aggarwal, N.T.; Chawengsub, Y.; Gauthier, K.M.; Viita, H.; Yla-Herttuala, S.; Campbell, W.B.
Endothelial 15-lipoxygenase-1 overexpression increases acetylcholine-induced hypotension and vasorelaxation in rabbits (2008), Hypertension, 51, 246-251.

Search for more literature for 1.13.11.33

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of isozyme 15-LO-1 in Oryctolagus cuniculus via adenovirus transfection method, the expression is restricted to aortic endothelial cells, overview	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	endothelial 15-lipoxygenase-1 overexpression in Oryctolagus cuniculus aortic endothelial cells increases acetylcholine-induced hypotension and vasorelaxation, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
arachidonate + O2	Homo sapiens	arachidonic acid is metabolized by the 15-lipoxygenase-1 pathway to the vasodilatory eicosanoids hydroxyepoxyeicosatrienoic acid and trihydroxyeicosatrienoic acid	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozyme 15-LO-1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	endothelial 15-LO-1 isozyme	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	-	Homo sapiens	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate	-	?
arachidonate + O2	arachidonic acid is metabolized by the 15-lipoxygenase-1 pathway to the vasodilatory eicosanoids hydroxyepoxyeicosatrienoic acid and trihydroxyeicosatrienoic acid	Homo sapiens	(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate	-	?

Synonyms

Synonyms	Comment	Organism
endothelial 15-lipoxygenase-1	-	Homo sapiens

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Release 2023.1 (January 2023)