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Literature summary for 1.13.11.31 extracted from

  • Rothe, T.; Gruber, F.; Uderhardt, S.; Ipseiz, N.; Roessner, S.; Oskolkova, O.; Blueml, S.; Leitinger, N.; Bicker, W.; Bochkov, V.N.; Yamamoto, M.; Steinkasserer, A.; Schett, G.; Zinser, E.; Kroenke, G.
    12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function (2015), J. Clin. Invest., 125, 1944-1954 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.31

Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme-deficient Alox15-/- mice, phenotype, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P16050
-
-
Mus musculus P39654
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Mus musculus C57BL/6 P39654
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-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell bone marrow-derived Homo sapiens
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dendritic cell bone marrow-derived Mus musculus
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T-lymphocyte
-
 Homo sapiens
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T-lymphocyte
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
12/15-lipoxygenase
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 Homo sapiens
12/15-lipoxygenase
-
 Mus musculus
12/15-LO
-
 Homo sapiens
12/15-LO
-
 Mus musculus
Alox15
-
 Homo sapiens
Alox15
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the cytokine expression profile of Alox15-/- dendritic cells show multiple alterations in comparison to that for wild-type dendritic cells. Alox15–/– dendritic cells display a shift in the mRNA and protein expression of different IL-12/IL-23 subunits and increased expression of the IL-23-specific subunit p19, whereas expression of the subunit p40 (shared by IL-12 and IL-23) is unaltered and the IL-12-specific subunit p35 is decreased. Alox15-deficient mice display an increased differentiation of Th17 cells and an aggravation of T cell–dependent autoimmune responses, Alox15-/- mice reveal significant increase in the expression of the IL-23 subunit p19, whereas expression levels of the IL-12/IL-23 subunits p35 and p40 are not significantly changed Mus musculus
malfunction the cytokine expression profile of Alox15-/- dendritic cells show multiple alterations in comparison to that for wild-type dendritic cells. Alox15–/– dendritic cells display a shift in the mRNA and protein expression of different IL-12/IL-23 subunits and increased expression of the IL-23-specific subunit p19, whereas expression of the subunit p40 (shared by IL-12 and IL-23) is unaltered and the IL-12-specific subunit p35 isdecreased Homo sapiens
physiological function 12/15-lipoxygenase-meditated (12/15-LO-mediated) enzymatic lipid oxidation regulates dendritic cell activation and fine-tunes consecutive T cell responses. 12/15-LO activity determines the dendritic cell activation threshold via generation of phospholipid oxidation products that induce an antioxidative response dependent on the transcription factor NRF2. Dendritic cells comprise a heterogenic group of antigen-presenting cells, which share the ability to prime naive T cells. 12/15-LO regulates the maturation process of human dendritic cell (DC). DC-intrinsic 12/15-LO activity attenuates Th17 T cell differentiation. NRF2 mediates the immune-modulatory effects of 12/15-LO-derived oxidized phospholipids Homo sapiens
physiological function 12/15-lipoxygenase-meditated (12/15-LO-mediated) enzymatic lipid oxidation regulates dendritic cell activation and fine-tunes consecutive T cell responses. 12/15-LO activity determines the dendritic cell activation threshold via generation of phospholipid oxidation products that induce an antioxidative response dependent on the transcription factor NRF2. Dendritic cells comprise a heterogenic group of antigen-presenting cells, which share the ability to prime naive T cells. 12/15-LO regulates the maturation process of human dendritic cell (DC). DC-intrinsic 12/15-LO activity attenuates Th17 T cell differentiation. NRF2 mediates the immune-modulatory effects of 12/15-LO-derived oxidized phospholipids Mus musculus